2022-01-21 General

Vaccines Pfizer had disappointing results with its first trial of COVID-19 vax for the under-5 year-olds. The youngest kids mounted an adequate response, but not the older kids, which to me says that the dose was too low. This article speculates that Pfizer will add a third minidose (3 mg, compared to the 50mg it… Continue reading 2022-01-21 General

2022-01-15/16/17 General

Treatments HOORAY!!! As this article reports, Health Canada approved Paxlovid (an oral treatment for COVID-19 which cuts hospitalizations by almost 90%) today! Not only that, there are already about 30K doses in-country! Supplies are going to be limited for a while. Until then, Health Canada recommends prioritizing severely immune-compromised patients, people over 80 who don’t… Continue reading 2022-01-15/16/17 General

2022-01-13 General

Variants Everybody knows by now that Omicron appears to be more mild, but how much of that is because lots of people have partial immunity? This preprint looked at South African Omicron infections and found that when you controlled for vaccination status, Omicron is about 25% as severe. Vaccines This article says that inactivated virus… Continue reading 2022-01-13 General

2022-01-07 General

Vaccines This preprint from the UK found that boosters help against symptomatic infection, but also wane: dose1&2 dose3 VE at 2-4 weeks VE at 5-9 weeks VE at >10 weeks AZ+AZ Pfizer 62-65% 48% 32% AZ+AZ Moderna 62-65% 56% N/A Pfizer+Pfizer Pfizer 65% 49% 31% Pfizer+Pfizer Moderna 70% 57% N/A However, protection against severe disease… Continue reading 2022-01-07 General

2022-01-06 General

Variants This preprint looks at the effectiveness of a COVID-19 infection (as opposed to a vaccination) against future COVID unpleasantness: Variant against infection against hospitalization or death Alpha 90.2% 69.4% Beta 84.8% 88.0% Delta 92.0% 100% Omicron 56.0% 87.8% This preprint says that most people have a quite good T-cell response to Omicron after a… Continue reading 2022-01-06 General

2022-01-05 General

Vaccines Studies of the effectiveness of boosters against Omicron in humans (as opposed to test tubes) are starting to come out, and they are not as encouraging as one would like. This preprint from the UK says in people who got AZ, a Pfizer booster is 89.1% effective against symptomatic infection and for those who… Continue reading 2022-01-05 General

2021-12-25/26/27/28 General

Variants There has been difficulty figuring out how badly Omicron is going to hit the hospital system first because it is a lagging indicator, second because Omicron affects vaccinated and unvaccinated people so differently, and third because of poor-quality data around the holidays. Still, there are hints that, as this tweet from New York says,… Continue reading 2021-12-25/26/27/28 General