2021-06-10 General

Vaccines AstraZeneca is in the process of developing a booster, AZD2816 (their original one was AZD1222), to do better against new strains. (As you might recall, AZD1222 is shit against Beta.) This paper says that it does well against all the strains in mice and test tubes. This article says there is a different AZ… Continue reading 2021-06-10 General

2021-06-09 General

Variants The Delta strain is spreading fast. This could be because it easier to catch (because infected people cough more often, infected people breath out more particles, or fewer virus particles are needed to get you sick, etc.) or because infected people become contagious more quickly. This study says that infected people don’t become contagious… Continue reading 2021-06-09 General

2021-06-08 General

Vaccines There are a fair number of studies about how many antibodies a given vaccine induces the patient to make, but this study seems to say that a lot of the antibodies which a patient produces in response to a vaccine aren’t actually useful at killing the virus. The antibodies you produce after getting a… Continue reading 2021-06-08 General

2021-06-07 General

Vaccines This paper found that antibodies from infection stick around for at least ten months. Given that vaccination is even better at making antibodies, this is a good sign for the vaccinated: it makes it less likely that we will need frequent boosters. According to this web page, Canada has a really low vax hesitancy… Continue reading 2021-06-07 General

2021-06-05/06 General

Vaccinations I love this chart: Yes, Canada has passed 60% of its population with at least one dose of a COVID-19 vaccine. Treatments Regeneron has gotten FDA approval for a lower-dose, injected (as opposed to transfused) version of its monoclonal antibody COVID-19 treatment, called REGEN-COV. This might be a big deal. The stuff works, but… Continue reading 2021-06-05/06 General

2021-06-03 General

Vaccines In general, I try not to post about things that people SAY are going to happen, preferring to wait until it actually happens. However, I am and have been quite excited about Novavax for a long time, so I am really pleased to hear that they are finally going to announce the results of… Continue reading 2021-06-03 General

2021-06-02 General

Vaccines This preprint says that in a very small study (26 participants) in Germany, a Pfizer boost after an AZ prime gave fewer side effects than the first dose (AZ). Based on in vitro measurements, AZ+Pf appeared to be at least as good as AZ+AZ. Antibodies were three times higher in AZ+Pf than AZ+AZ, and… Continue reading 2021-06-02 General

2021-06-01 General

Vaccines Canada’s National Advisory Committee on Immunizations has decreed that it’s okay to get an mRNA shot after an AstraZeneca shot. They had been waiting for the efficacy results from a big UK study, but the study has been delayed another month, and they (along with many other immunology boards) finally said “screw it, we’re… Continue reading 2021-06-01 General

2021-05-31 General

Vaccines I have been very excited about NDV-HXP-S, which uses a 6-proline substitution (which makes the spike protein more stable) of the spike protein called Hexapro. Well, today a preprint came out with preliminary results that have two really good results in mice modified to have a human immune system. First, they developed an awesome… Continue reading 2021-05-31 General

2021-05-29 General

Vaccines If I understand this paper correctly, scientists found spike protein in the blood of mice after vaccinating them with AZ. (See previous discussion of why that matters in the 26 May General blog posting.) There have been a number of papers which say that you are much less likely to transmit COVID if you… Continue reading 2021-05-29 General