2021-05-20 General

Vaccines SinoVac/CoronaVac did a clinical trial in kids down to age 3. They found that compared to adults, the kids had better immune responses and fewer side-effects. They also tested full-doses vs. half-doses, and while a half-dose might be enough for the smallest kids, it interestingly didn’t make the side-effects any better. That surprised me:… Continue reading 2021-05-20 General

2021-05-19 General

Disease This preprint found that patients with COVID-19 made a bunch of antibodies which attacked their own innate immune system. Putting those antibodies into mice with a human ACE2 receptor made them more susceptible to COVID-19. Remember yesterday, how I talked at length about how live attenuated virus vaccines (LAVs) appear to rev up the… Continue reading 2021-05-19 General

2021-05-13 General

Vaccines There are lots of papers which look at antibodies — because antibodies (made by B cells) are comparatively easy to measure. Over and over, I’ve seen papers saying that some specific vax does not generate as many antibodies against some specific variant than against COVID Classic. By contrast, this paper looks at T-cells in… Continue reading 2021-05-13 General

2021-05-12 General

Variants There is a somewhat worrying report from Qatar saying that the efficacy of only one dose of Pfizer is only 29.5% against infection from B.1.1.7 and 54% against hospitalization. If you only have one dose, maybe don’t go licking doorknobs just yet. However, this report, also out today, from the UK from December to… Continue reading 2021-05-12 General

2021-05-11 General

Secondary Effects A study in the UK says that diabetes diagnosis, management, and mortality have been impacted pretty badly during the pandemic. 🙁 Vaccinations Today, Canada passed the 40% mark in what percentage of its population has gotten at least one dose, and it doesn’t look like the vaccination rate is slowing down at all!… Continue reading 2021-05-11 General

2021-05-10 General

Vaccines This preprint says that scientists have seen good results of a multi-coronavirus vaccine, working against SARS-CoV-1, COVID Classic, B.1.1.7, B.1.351, and bat coronaviruses! Disease From this preprint, 2% of the people with COVID-19 carry 90% of the virions! This preprint is from August, but I just noticed it. It says that COVID-19 cases go… Continue reading 2021-05-10 General

2021-05-08 General

Immunity A huuuge study in Denmark looked for reinfections and from that, figured out the efficacy of getting sick in preventing later infections and found that it was 80·5%, 47·1% for those aged 65 years and older. And yes, mRNA vaccines are like 95% efficient, so yes, the mRNA vaccines are higher efficacy than actually… Continue reading 2021-05-08 General

2021-05-07 General

Drug interactions Apparently some people were worried that Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) would make a COVID infection worse. Not so, says this study. Variants Remember yesterday when I said that B.1.617.2 was not of concern? I was too fast. While it does not seem to have unusually good immunity/vaccine evasion, it does seem to be… Continue reading 2021-05-07 General