Vaccines This preprint says that in a very small study (26 participants) in Germany, a Pfizer boost after an AZ prime gave fewer side effects than the first dose (AZ). Based on in vitro measurements, AZ+Pf appeared to be at least as good as AZ+AZ. Antibodies were three times higher in AZ+Pf than AZ+AZ, and… Continue reading 2021-06-02 General
Category: Vaccines
2021-06-01 General
Vaccines Canada’s National Advisory Committee on Immunizations has decreed that it’s okay to get an mRNA shot after an AstraZeneca shot. They had been waiting for the efficacy results from a big UK study, but the study has been delayed another month, and they (along with many other immunology boards) finally said “screw it, we’re… Continue reading 2021-06-01 General
2021-05-31 General
Vaccines I have been very excited about NDV-HXP-S, which uses a 6-proline substitution (which makes the spike protein more stable) of the spike protein called Hexapro. Well, today a preprint came out with preliminary results that have two really good results in mice modified to have a human immune system. First, they developed an awesome… Continue reading 2021-05-31 General
2021-05-29 General
Vaccines If I understand this paper correctly, scientists found spike protein in the blood of mice after vaccinating them with AZ. (See previous discussion of why that matters in the 26 May General blog posting.) There have been a number of papers which say that you are much less likely to transmit COVID if you… Continue reading 2021-05-29 General
2021-05-27 General
Mitigation Measures Whaddayaknow, masks work. This literature review says so. Variants B.1.617.2 is now dominant in the UK. This is legit something to worry about, as one dose of vax is only about half as good as two doses. Vaccines Some scientists think that COVID-19 immunity from vaccines will last years, if not a lifetime.… Continue reading 2021-05-27 General
2021-05-26 General
Treatments This article explains how scientists can now make mini organs — like mini-lungs and mini-hearts — and infect them with COVID-19 to see what happens. This has the potential to make it much faster to try out different treatments. 😲 This paper reports that a nasal antibody spray can help hamsters recover from COVID-19.… Continue reading 2021-05-26 General
2021-05-25 General
Mitigation Measures This paper looked at movement restrictions in the US and found the following (independent) reductions in mobility from mitigation measures: Measure Reduction emergency declaration 9.9% social distancing policies 24.5% shelter-in-place 29% Further, they found that a 10% reduction in mobility was associated with a 17.5% reduction in case growth two weeks later. Vaccines… Continue reading 2021-05-25 General
2021-05-24 General
Diagnostics Dear Readers, go get yourself a pulse oximeter. A study showed that frequently people with COVID wait until they are short of breath to go to hospital. Unfortunately, with COVID, frequently you feel like you can breathe fine, but your blood oxygen actually is quite low. If your pulse oximeter is reading low and… Continue reading 2021-05-24 General
2021-05-22/23 General
Yesterday was a bit of a slow news day, plus I uh forgot to hit the Publish button, so today you get a 2-for-1 post! Schools A US CDC report says that schools that required teachers and staff to use masks had 37% lower rates of COVID-19. Schools which improved ventilation had 39% lower rates… Continue reading 2021-05-22/23 General
2021-05-21 General
Vaccines New data from a UK study of Novavax is out, and it looks really good: 96.4% against COVID Classic and 86.3% against B.1.1.7, with fewer side effects than Pfizer/Moderna/AZ. (No sign of blood clots, either, but rare events like that are unlikely to show up in a trial.) Meanwhile, a Novavax trial in South… Continue reading 2021-05-21 General