Genetics This preprint talks about using virus-like particles to study viruses. It looks enough like SARS-CoV-2 that it can get into cells, but then it can’t replicate. Essentially, it’s shooting blanks. This study identified a specific gene variant (which comes from Neanderthals!) which gives a 2x risk of respiratory failure. About 60% of people of… Continue reading 2021-11-04 General
Category: Mitigation Measures
2021-11-02 General
Vaccines This article says that vaccine effectiveness in England was only about 50-60% against infection in the June/July 2021 period. There’s a stat called the number needed to vaccinate (NNV), which is a measure of how many people you would need to vaccinate to prevent some outcome. The NNV for 80 year olds to prevent… Continue reading 2021-11-02 General
2021-10-21 General
Mitigation Measures This article talks about $7.4B in relief spending that the Government of Canada has announced. All three of these programs will go until 7 May 2022. Canada Recovery Benefit (CRB) will be replaced by the Canada Worker Lockdown Benefit and will provide $300 a week to eligible people. The Tourism and Hospitality Recovery… Continue reading 2021-10-21 General
2021-10-16/17/18 General
Vaccines This study in Sweden of mix&match effectiveness against symptomatic infection found that a second dose of mRNA was better after a first of AZ than a second dose of AZ: 1st Dose 2nd Dose Effectiveness AZ AZ 50% AZ Pfizer 67% AZ Moderna 79% Pfizer Pfizer 78% Moderna Moderna 87% This article says that… Continue reading 2021-10-16/17/18 General
2021-10-15 General
A friend kept ragging on me about using the trade names for various vaccines. I held firm because it was more correct and accurate. He complained that nobody knew the names, but I pointed out that people got used to Alpha, Beta, Gamma, and Delta. I now give up. Nobody and I mean nobody but… Continue reading 2021-10-15 General
2021-10-13 General
Diagnosis / Equity This Twitter thread suggests that the reason darker-skinned people have higher fatality rates from COVID-19 is because, well, they have darker skin: pulse oximeters, which are used to judge how serious a case is, don’t work on dark-skinned people. Economic effects This video from January 2021 makes the economic case — not… Continue reading 2021-10-13 General
2021-10-08 General
Risk Factors This preprint says that having a bad mutation on the (X-linked) TLR7 gene is very very bad for your COVID-19 prospects. The authors think this accounts for about 1.8% of severe COVID-19 in male patients under 60. But here’s some good news on genes: this preprint says that a change in one nucleotide… Continue reading 2021-10-08 General
2021-10-06 General
Mitigation Measures This article says that the Government of Canada has come out with new vaccine mandates. All federal employees — including those who work from home or in a different country — have until 29 October to get vaccinated. Everyone over 12 must be vaccinated to take a plane or train inside Canada. Transmission… Continue reading 2021-10-06 General
2021-09-28 General
Treatments It’s been observed often that obesity raises the risk of COVID-19. This preprint looked into it more closely, and found that the anti-obesity drug orlistat blocks COVID-19 in mice. Mitigation Measures This report from England looked how behaviour correlated with risk of getting COVID-19. People who reported that never wore masks were slightly over… Continue reading 2021-09-28 General
2021-09-25/26/27 General
Pathology A paper last week said that the risk of heart inflammation in young men was one in a thousand. As this article reports, they were waaaaaay off in their count of the total number of vaccinations in Ontario; the correct figure turns out to be one in 1 in 25,000. I can’t for the… Continue reading 2021-09-25/26/27 General