Vaccines This study in Israel of people over 60 found that the risk of infection dropped in half after their fourth dose of vaccine; the risk of severe illness dropped by a fourth. Note that this sounds really good, but the study was only in people over 60, and there’s no information on waning. Pathology… Continue reading 2022-02-01 General
Category: Vaccines
2022-01-29/30/31 General
Vaccines There’s a great, long Twitter thread which looks at the effect of vaccines. (It summarizes a paywalled article, if you want to see the whole thing.) One of the elements which I found striking was how the risk of COVID-19 relative to the flu has dropped over time. In mid 2020, the infection fatality… Continue reading 2022-01-29/30/31 General
2022-01-31 Booster Recommendation
I am putting this here in a stand-alone document so that I can refer to it easily. People have been asking me which booster they should get, Pfizer or Moderna? For effectiveness, the answer is always Moderna, though it’s not so bad if you get Pfizer. All the studies I have seen say that Moderna… Continue reading 2022-01-31 Booster Recommendation
2022-01-28 General
Variants I don’t like to warn about variants before there’s data. (I didn’t sound alarms about Mu, for example.) Well, I think it’s time to talk about BA.2 — an Omicron variant. (The Omicron variant which sprouted up first is BA.1.) BA.2 doesn’t look like it is lot worse than BA.1 — not like Delta… Continue reading 2022-01-28 General
2022-01-27 General
Pathology This study found that pregnant women were 1.77x as likely to develop preeclampsia if they got COVID-19; women who had not given birth before were 1.89x as likely. They found the risk of a preterm birth for all pregnant women with both COVID-19 and preeclampsia was 4.05x (and 6.26x for women who had never… Continue reading 2022-01-27 General
2022-01-26 General
Mitigation Measures This preprint looked at high-risk exposures and said that the risk of catching COVID-19 was: 3.02x higher if the infected person was part of your household (versus not), 2.1x higher if the transmission was indoors (versus outdoors), 2.15x higher if the interaction lasted 3 hrs or more (vs. shorter) among unvaccinated and partially-vaccinated… Continue reading 2022-01-26 General
2022-01-25 General
Long COVID This preprint says that they found four predictors which are strongly correlated with Long COVID: type 2 diabetes, SARS-CoV-2 RNA in the blood, Epstein-Barr virus in the blood, and specific autoantibodies. (Here’s an article translating the subject into lay-speak. Paywalled, sorry.) This paper also found a Long COVID signature/diagnostic, this time in age,… Continue reading 2022-01-25 General
2022-01-21 General
Vaccines Pfizer had disappointing results with its first trial of COVID-19 vax for the under-5 year-olds. The youngest kids mounted an adequate response, but not the older kids, which to me says that the dose was too low. This article speculates that Pfizer will add a third minidose (3 mg, compared to the 50mg it… Continue reading 2022-01-21 General
2022-01-19 General
Vaccines This preprint says that there were zero children in France who had been fully vaccinated and went on to develop MIS-C. Pathology This preprint says that kids recover pretty well from MIS-C. This speculative preprint wonders if maybe the reason kids have milder symptoms and MIS-C after a delay is because their bodies make… Continue reading 2022-01-19 General
2022-01-15/16/17 General
Treatments HOORAY!!! As this article reports, Health Canada approved Paxlovid (an oral treatment for COVID-19 which cuts hospitalizations by almost 90%) today! Not only that, there are already about 30K doses in-country! Supplies are going to be limited for a while. Until then, Health Canada recommends prioritizing severely immune-compromised patients, people over 80 who don’t… Continue reading 2022-01-15/16/17 General