Vaccines This article reports that Health Canada approved the Pfizer booster for everyone over 18 today. This study gives the Phase 3 results for the pediatric Pfizer shots, showing a vaccine effectiveness of 90.7%. Recommended Reading This article is about the theory of risk compensation — which they say is bogus and harmful. You won’t… Continue reading 2021-11-09 General
Category: General
2021-11-06/7/8 General
Disease As I mentioned back in May 2020, they discovered a new coronavirus in Malaysia in samples from 2017 and 2018 which appears to have jumped directly from dogs to humans. They found this coronavirus because someone decided to go looking for unknown coronaviruses, and whaddayaknow, there one is! There wasn’t a big fuss because… Continue reading 2021-11-06/7/8 General
2021-11-05 General
Treatment Fantastic news! Pfizer has a pill which, if you take it in the first three days after symptoms appear, cuts hospitalization by NINETY F PERCENT!!! If taken within the first five days, it’s ~85% effective. The pill, called Paxlovid, is a protease inhibitor, which ought to be easy to make and have low side… Continue reading 2021-11-05 General
2021-11-04 General
Genetics This preprint talks about using virus-like particles to study viruses. It looks enough like SARS-CoV-2 that it can get into cells, but then it can’t replicate. Essentially, it’s shooting blanks. This study identified a specific gene variant (which comes from Neanderthals!) which gives a 2x risk of respiratory failure. About 60% of people of… Continue reading 2021-11-04 General
2021-11-03 General
Deaths/Demographics In addition to just “numbers of deaths”, you can also estimate “years of life lost” to describe how bad an epidemic is. For example, HIV had a huuuuge number of years of life lost because the people who died from it were unusually young. This article looked at years of life lost to COVID-19… Continue reading 2021-11-03 General
2021-11-02 General
Vaccines This article says that vaccine effectiveness in England was only about 50-60% against infection in the June/July 2021 period. There’s a stat called the number needed to vaccinate (NNV), which is a measure of how many people you would need to vaccinate to prevent some outcome. The NNV for 80 year olds to prevent… Continue reading 2021-11-02 General
2021-10-30 to 11-01 General
Vaccines This preprint from Israel says that the vaccine effectiveness of a third dose of Pfizer vs. two doses of Pfizer at least five months ago was: 93% against hospitalization, 92% against severe disease (which I think is equivalent to “ICU” here), 81% against death. This article says that Novavax has finished its rolling review… Continue reading 2021-10-30 to 11-01 General
2021-10-29 General
Vaccines This article says that NACI recommended boosters for a few more groups: People who got two doses of AZ or one of J&J, on the grounds that those seem to wane over time. People over 70 who could become severely ill from the disease. People from First Nations, Inuit and Metis communities. Front-line health-care… Continue reading 2021-10-29 General
2021-10-28 General
Treatment This paper says that a single infusion of a new-to-me polyclonal antibody — sotrovimab — is 85% effective at preventing hospitalization when given early to high-risk COVID-19 patients. The FDA already gave an EUA to sotrovimab on 26 May; Canada gave interim approval on 30 July (and bought 10,000 doses on 4 October), so… Continue reading 2021-10-28 General
2021-10-27 General
Treatments Yay! This article says that Merck has licensed molnupiravir such that ~100 developing countries can manufacture it at low cost! This is awesome. (It hasn’t been approved by any countries yet, but it will be soon, I’m sure.) Yay yay! This article reports that a cheap mature drug for depression — fluvoxamine — reduces… Continue reading 2021-10-27 General