Genetics This preprint talks about using virus-like particles to study viruses. It looks enough like SARS-CoV-2 that it can get into cells, but then it can’t replicate. Essentially, it’s shooting blanks. This study identified a specific gene variant (which comes from Neanderthals!) which gives a 2x risk of respiratory failure. About 60% of people of… Continue reading 2021-11-04 General
Category: Vaccines
2021-11-03 General
Deaths/Demographics In addition to just “numbers of deaths”, you can also estimate “years of life lost” to describe how bad an epidemic is. For example, HIV had a huuuuge number of years of life lost because the people who died from it were unusually young. This article looked at years of life lost to COVID-19… Continue reading 2021-11-03 General
2021-11-02 General
Vaccines This article says that vaccine effectiveness in England was only about 50-60% against infection in the June/July 2021 period. There’s a stat called the number needed to vaccinate (NNV), which is a measure of how many people you would need to vaccinate to prevent some outcome. The NNV for 80 year olds to prevent… Continue reading 2021-11-02 General
2021-10-30 to 11-01 General
Vaccines This preprint from Israel says that the vaccine effectiveness of a third dose of Pfizer vs. two doses of Pfizer at least five months ago was: 93% against hospitalization, 92% against severe disease (which I think is equivalent to “ICU” here), 81% against death. This article says that Novavax has finished its rolling review… Continue reading 2021-10-30 to 11-01 General
2021-10-29 General
Vaccines This article says that NACI recommended boosters for a few more groups: People who got two doses of AZ or one of J&J, on the grounds that those seem to wane over time. People over 70 who could become severely ill from the disease. People from First Nations, Inuit and Metis communities. Front-line health-care… Continue reading 2021-10-29 General
2021-10-27 General
Treatments Yay! This article says that Merck has licensed molnupiravir such that ~100 developing countries can manufacture it at low cost! This is awesome. (It hasn’t been approved by any countries yet, but it will be soon, I’m sure.) Yay yay! This article reports that a cheap mature drug for depression — fluvoxamine — reduces… Continue reading 2021-10-27 General
2021-10-23/24/25 General
Transmission In this small study of Italian health-care workers who were tested regularly, all of the people who tested positive but were asymptomatic tested negative the very next day. The mean time for the symptomatic patients to test negative was 11 days. Pathology This preprint says they found SARS-CoV-2 antibodies in the cerebrospinal fluid of… Continue reading 2021-10-23/24/25 General
2021-10-22 General
Vaccines This article reports that pediatric Pfizer is 90.7% effective against infection in children. Long COVID This preprint says that various forms of cognitive impairment are pretty common several months after “getting over” COVID-19. People who went the ER are more likely to have cognitive impairment than people who were treated as outpatients. Recommended Reading… Continue reading 2021-10-22 General
2021-10-21 General
Mitigation Measures This article talks about $7.4B in relief spending that the Government of Canada has announced. All three of these programs will go until 7 May 2022. Canada Recovery Benefit (CRB) will be replaced by the Canada Worker Lockdown Benefit and will provide $300 a week to eligible people. The Tourism and Hospitality Recovery… Continue reading 2021-10-21 General
2021-10-19 General
Vaccines This preprint is yet another study showing that infection+vaccination gives a stronger and more durable response that vaccination alone or infection alone. There have been so many studies showing that result that I am getting tired and bored with them, and probably will not post any more. This preprint about vaccines and pregnancy found:… Continue reading 2021-10-19 General