Pathology This study found that pregnant women were 1.77x as likely to develop preeclampsia if they got COVID-19; women who had not given birth before were 1.89x as likely. They found the risk of a preterm birth for all pregnant women with both COVID-19 and preeclampsia was 4.05x (and 6.26x for women who had never… Continue reading 2022-01-27 General
Category: Vaccines
2022-01-26 General
Mitigation Measures This preprint looked at high-risk exposures and said that the risk of catching COVID-19 was: 3.02x higher if the infected person was part of your household (versus not), 2.1x higher if the transmission was indoors (versus outdoors), 2.15x higher if the interaction lasted 3 hrs or more (vs. shorter) among unvaccinated and partially-vaccinated… Continue reading 2022-01-26 General
2022-01-25 General
Long COVID This preprint says that they found four predictors which are strongly correlated with Long COVID: type 2 diabetes, SARS-CoV-2 RNA in the blood, Epstein-Barr virus in the blood, and specific autoantibodies. (Here’s an article translating the subject into lay-speak. Paywalled, sorry.) This paper also found a Long COVID signature/diagnostic, this time in age,… Continue reading 2022-01-25 General
2022-01-21 General
Vaccines Pfizer had disappointing results with its first trial of COVID-19 vax for the under-5 year-olds. The youngest kids mounted an adequate response, but not the older kids, which to me says that the dose was too low. This article speculates that Pfizer will add a third minidose (3 mg, compared to the 50mg it… Continue reading 2022-01-21 General
2022-01-19 General
Vaccines This preprint says that there were zero children in France who had been fully vaccinated and went on to develop MIS-C. Pathology This preprint says that kids recover pretty well from MIS-C. This speculative preprint wonders if maybe the reason kids have milder symptoms and MIS-C after a delay is because their bodies make… Continue reading 2022-01-19 General
2022-01-15/16/17 General
Treatments HOORAY!!! As this article reports, Health Canada approved Paxlovid (an oral treatment for COVID-19 which cuts hospitalizations by almost 90%) today! Not only that, there are already about 30K doses in-country! Supplies are going to be limited for a while. Until then, Health Canada recommends prioritizing severely immune-compromised patients, people over 80 who don’t… Continue reading 2022-01-15/16/17 General
2022-01-13 General
Variants Everybody knows by now that Omicron appears to be more mild, but how much of that is because lots of people have partial immunity? This preprint looked at South African Omicron infections and found that when you controlled for vaccination status, Omicron is about 25% as severe. Vaccines This article says that inactivated virus… Continue reading 2022-01-13 General
2022-01-12 General
Transmission Yesterday in the BC blog post, I gave a bunch of evidence for Omicron being a very “pointy” wave, fast up and fast down. Wastewater evidence from the eastern USA is also pointing to fast-up/fast-down. From this tweet, the wastewater SARS-CoV-2 surveillance in Boston: And from this tweet, the surveillance in New Haven, CT:… Continue reading 2022-01-12 General
2022-01-07 General
Vaccines This preprint from the UK found that boosters help against symptomatic infection, but also wane: dose1&2 dose3 VE at 2-4 weeks VE at 5-9 weeks VE at >10 weeks AZ+AZ Pfizer 62-65% 48% 32% AZ+AZ Moderna 62-65% 56% N/A Pfizer+Pfizer Pfizer 65% 49% 31% Pfizer+Pfizer Moderna 70% 57% N/A However, protection against severe disease… Continue reading 2022-01-07 General
2022-01-06 General
Variants This preprint looks at the effectiveness of a COVID-19 infection (as opposed to a vaccination) against future COVID unpleasantness: Variant against infection against hospitalization or death Alpha 90.2% 69.4% Beta 84.8% 88.0% Delta 92.0% 100% Omicron 56.0% 87.8% This preprint says that most people have a quite good T-cell response to Omicron after a… Continue reading 2022-01-06 General