Vaccines Oh, ouch! CureVac has really crappy preliminary Phase 3 results: 49%. CureVac is an mRNA vax, and they had made all kinds of partnerships with really big pharma companies to manufacture it. They were supposed to deliver 300M this year and 1B next year. That hurts. A survey says that about one in five… Continue reading 2021-06-16 General
Category: General
2021-06-15 General
Vaccines A few days ago, I wrote about how the world was going to have more than enough vaccine for everybody by the end of the year, and listed all the vaccines which I thought would be approved in time to help people this year? Well, one that had not even been on my radar… Continue reading 2021-06-15 General
2021-06-14 General
Vaccines Novavax announced that they have finished their Phase 3 trials with a 90.4% efficacy rate (with two-thirds of the infections being the Alpha strain). Their reported rate of “mild” (i.e. “only” make you uncomfortable) side effects was lower than any of the other Canadian-approved vaxes. Novavax says they will seek FDA approval “in Q3”,… Continue reading 2021-06-14 General
2021-06-13 General
Supply Tl;dr: we have enough supply to vax the world before the end of 2021. I hear a lot of people being very concerned about the global supply, worried that it will be multiple years before we have enough doses to vax the world. I think there is a really good chance that we will… Continue reading 2021-06-13 General
2021-06-12 General
Vaccines This paper says that women have a more robust response to vaccination than men do. On 18 May, I talked about how live attenuated virus vaccines seem to rev up the innate immune system. I mentioned in that post that a smallpox vaccination reduced all-cause mortality more than attributable to smallpox deaths; I had… Continue reading 2021-06-12 General
2021-06-11 General
Vaccines The US FDA told Johnson & Johnson that they had to scrap fucking sixty fucking million fucking doses of their vaccine because of fucking problems at their fucking Baltimore plant. This is heartbreaking. This matters outside of the USA because some of those doses went to other countries. For example, Canada has 300K doses… Continue reading 2021-06-11 General
2021-06-10 General
Vaccines AstraZeneca is in the process of developing a booster, AZD2816 (their original one was AZD1222), to do better against new strains. (As you might recall, AZD1222 is shit against Beta.) This paper says that it does well against all the strains in mice and test tubes. This article says there is a different AZ… Continue reading 2021-06-10 General
2021-06-09 General
Variants The Delta strain is spreading fast. This could be because it easier to catch (because infected people cough more often, infected people breath out more particles, or fewer virus particles are needed to get you sick, etc.) or because infected people become contagious more quickly. This study says that infected people don’t become contagious… Continue reading 2021-06-09 General
2021-06-08 General
Vaccines There are a fair number of studies about how many antibodies a given vaccine induces the patient to make, but this study seems to say that a lot of the antibodies which a patient produces in response to a vaccine aren’t actually useful at killing the virus. The antibodies you produce after getting a… Continue reading 2021-06-08 General
2021-06-07 General
Vaccines This paper found that antibodies from infection stick around for at least ten months. Given that vaccination is even better at making antibodies, this is a good sign for the vaccinated: it makes it less likely that we will need frequent boosters. According to this web page, Canada has a really low vax hesitancy… Continue reading 2021-06-07 General