Variants As this article says, they are starting to see a new variant in England called AY.4.2 or “Delta plus”. It is gaining ground on Delta, although slowly. It might be a little bit more contagious than Delta, but not hugely. It’s not like the huge advantage over Alpha that Delta had. Recommended Reading This… Continue reading 2021-10-20 General
Category: General
2021-10-19 General
Vaccines This preprint is yet another study showing that infection+vaccination gives a stronger and more durable response that vaccination alone or infection alone. There have been so many studies showing that result that I am getting tired and bored with them, and probably will not post any more. This preprint about vaccines and pregnancy found:… Continue reading 2021-10-19 General
2021-10-16/17/18 General
Vaccines This study in Sweden of mix&match effectiveness against symptomatic infection found that a second dose of mRNA was better after a first of AZ than a second dose of AZ: 1st Dose 2nd Dose Effectiveness AZ AZ 50% AZ Pfizer 67% AZ Moderna 79% Pfizer Pfizer 78% Moderna Moderna 87% This article says that… Continue reading 2021-10-16/17/18 General
2021-10-15 General
A friend kept ragging on me about using the trade names for various vaccines. I held firm because it was more correct and accurate. He complained that nobody knew the names, but I pointed out that people got used to Alpha, Beta, Gamma, and Delta. I now give up. Nobody and I mean nobody but… Continue reading 2021-10-15 General
2021-10-14 General
Vaccines Someone is live-tweeting the La Jolla Immunology Conference, and during a panel about an important paper from May that I’ve already talked about, they said something which I missed: that inter-individual variations in antibody responses are larger than the variations between responses to different variants. I’ve talked about the two-proline (2P) and six-proline (6P)… Continue reading 2021-10-14 General
2021-10-13 General
Diagnosis / Equity This Twitter thread suggests that the reason darker-skinned people have higher fatality rates from COVID-19 is because, well, they have darker skin: pulse oximeters, which are used to judge how serious a case is, don’t work on dark-skinned people. Economic effects This video from January 2021 makes the economic case — not… Continue reading 2021-10-13 General
2010-10-09/10/11/12 General
Mitigation Measures This article says that the US will allow fully-vaccinated Canadians to enter, starting sometime in November. “Fully-vaccinated” has not been clearly defined yet. Vaccines Novavax has published data from their Phase 3 trials in the USA and Mexico in this preprint. I wanted to be snarky and say that maybe this means that… Continue reading 2010-10-09/10/11/12 General
2021-10-08 General
Risk Factors This preprint says that having a bad mutation on the (X-linked) TLR7 gene is very very bad for your COVID-19 prospects. The authors think this accounts for about 1.8% of severe COVID-19 in male patients under 60. But here’s some good news on genes: this preprint says that a change in one nucleotide… Continue reading 2021-10-08 General
2021-10-07 General
Long COVID This study from the UK found: there were subtle differences in T cells which correlated strongly (but not perfectly) with having Long COVID; giving histamine receptor antagonists made 72% of them better (!!!); something which the histamine receptor antagonists never helped was dysautonomia, which suggests that there is some different mechanism causing that.… Continue reading 2021-10-07 General
2021-10-06 General
Mitigation Measures This article says that the Government of Canada has come out with new vaccine mandates. All federal employees — including those who work from home or in a different country — have until 29 October to get vaccinated. Everyone over 12 must be vaccinated to take a plane or train inside Canada. Transmission… Continue reading 2021-10-06 General