Vaccinations I love this chart: Yes, Canada has passed 60% of its population with at least one dose of a COVID-19 vaccine. Treatments Regeneron has gotten FDA approval for a lower-dose, injected (as opposed to transfused) version of its monoclonal antibody COVID-19 treatment, called REGEN-COV. This might be a big deal. The stuff works, but… Continue reading 2021-06-05/06 General
Category: General
2021-06-04 General
Disease One odd thing about COVID-19 is that patients would show up at the hospital with really, really low oxygen in their blood despite having no trouble breathing. This study has an explanation: red blood cells getting killed, but with some subtlety. Immature red blood cells form in the bone marrow. They have a nucleus… Continue reading 2021-06-04 General
2021-06-03 General
Vaccines In general, I try not to post about things that people SAY are going to happen, preferring to wait until it actually happens. However, I am and have been quite excited about Novavax for a long time, so I am really pleased to hear that they are finally going to announce the results of… Continue reading 2021-06-03 General
2021-06-02 General
Vaccines This preprint says that in a very small study (26 participants) in Germany, a Pfizer boost after an AZ prime gave fewer side effects than the first dose (AZ). Based on in vitro measurements, AZ+Pf appeared to be at least as good as AZ+AZ. Antibodies were three times higher in AZ+Pf than AZ+AZ, and… Continue reading 2021-06-02 General
2021-06-01 General
Vaccines Canada’s National Advisory Committee on Immunizations has decreed that it’s okay to get an mRNA shot after an AstraZeneca shot. They had been waiting for the efficacy results from a big UK study, but the study has been delayed another month, and they (along with many other immunology boards) finally said “screw it, we’re… Continue reading 2021-06-01 General
2021-05-31 General
Vaccines I have been very excited about NDV-HXP-S, which uses a 6-proline substitution (which makes the spike protein more stable) of the spike protein called Hexapro. Well, today a preprint came out with preliminary results that have two really good results in mice modified to have a human immune system. First, they developed an awesome… Continue reading 2021-05-31 General
2021-05-29 General
Vaccines If I understand this paper correctly, scientists found spike protein in the blood of mice after vaccinating them with AZ. (See previous discussion of why that matters in the 26 May General blog posting.) There have been a number of papers which say that you are much less likely to transmit COVID if you… Continue reading 2021-05-29 General
2021-05-28 General
Variants This paper says that the antibody response from a Pfizer vax to B.1.1.7 and B.1.351 is lower, but the T-cell response is just fine. That means there will be a few more cases in a B.1.1.7- or B.1.351-rich environment, but there won’t be severe cases. A lot of people are worried about the B.1.617.2… Continue reading 2021-05-28 General
2021-05-27 General
Mitigation Measures Whaddayaknow, masks work. This literature review says so. Variants B.1.617.2 is now dominant in the UK. This is legit something to worry about, as one dose of vax is only about half as good as two doses. Vaccines Some scientists think that COVID-19 immunity from vaccines will last years, if not a lifetime.… Continue reading 2021-05-27 General
2021-05-26 General
Treatments This article explains how scientists can now make mini organs — like mini-lungs and mini-hearts — and infect them with COVID-19 to see what happens. This has the potential to make it much faster to try out different treatments. 😲 This paper reports that a nasal antibody spray can help hamsters recover from COVID-19.… Continue reading 2021-05-26 General