Someone asked me to keep a list of drugs which looked like they would work against COVID. Wikipedia has a list, a bit outdated. I plan to do more work on this in the future.
These are certainly good:
- Dexamethasone, 17% mortality reduction
- IL-6 blockers, 24% mortality reduction on top of dexamethasone
- Bamlanivimab plus Etesevimab (together) — monoclonal antibodies (co-developed by Vancouver company AbCellera!} reduced hospitalization/death by 85%-87%. Unfortunately, it takes an infusion, which is a PITA to administer.
These might be good:
- Fluvoxamine — Seems to prevent mild cases from getting serious, apparently by inhibiting the inflammatory response. Very small study but the drug is very safe. 60 Minutes had a story on it.
- peginterferon lambda
- Ivermectin – Suppresses COVID in vitro, but at levels higher than are approved in humans. In vivo studies have not yet shown that it helps.
- Vitamin D – There are a lot of small studies which show that Vitamin D is really useful (or perhaps that Vitamin D deficiency — which is very common — is really bad if you catch COVID). Larger studies are underway but have not yet proved anything.
- tocilizumab — One study said it was good, another study said it was not. The editors tried to figure out why.
- inhaled budesonide — one study says that it reduces hospitalization, fever, recovery period
- amodiaquine (an antimalarial) shows good results in hamsters
- ADG20, a monoclonal antibody
These have been proven to be unhelpful:
- Convalescent plasma
- Colchicine — old drug for gout, sometimes used for cardiac issues — not statistically significant