2022-01-06 General

Variants

This preprint looks at the effectiveness of a COVID-19 infection (as opposed to a vaccination) against future COVID unpleasantness:

Variantagainst infectionagainst hospitalization or death
Alpha90.2%69.4%
Beta84.8%88.0%
Delta92.0%100%
Omicron56.0%87.8%

This preprint says that most people have a quite good T-cell response to Omicron after a COVID-19 infection or vaccination, but ~20% have a really crappy response. Boosters help, but even after boosting, ~9% still had a crappy response.

Neither age nor sex nor vaccine brand correlated with whether you had a good response or a crappy response. Infection did give a bit higher T-cell response than vaccination.

Transmission

This preprint says you can estimate the reproductive number by looking at a random sample of Ct levels in your population.

Long COVID

This study found that elite soccer players in Germany and Italy’s performance declined 6% after recovering from COVID-19, and was down 5% even a year later. This lay article about the study points out that elite pro athletes are young, fit, and highly able to get world-class medical care; the rest of us are not as lucky.


This meta-analysis of 81 different papers on Long COVID found that:

  • About a third of patients have fatigue at 12 weeks, and almost as many still have fatigue after six months.
  • Slightly over one fifth of patients have cognitive impairment at 12 weeks, and almost as many still have it after six months.
    • In other words, fatigue and cognitive impairment basically doesn’t get better.
  • Fatigue and cognitive impairment were not statistically significantly different between hospitalized and non-hospitalized patients.
  • Adults had fatigue at about 3x the rate of children.
  • Adults had cognitive impairment at about 2.5x the rate of children.
  • The studies reported that between ~30% and ~50% (depending on the study) of patients were not able to return to work.

Recommended Reading

This long Twitter thread talks about Long COVID from many angles.

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